What is the purpose of the study?

The purpose of this research is to understand how smokers’ responses to naltrexone and stress relate to smoking, smoking cessation, and relapse.

How often are the clinic visits?

If you are a smoker, we expect that you will be in this research study for a total of up to around 18-20 hours over the course of about 4 months or less, though it is possible that the researcher will ask you to schedule follow-up visits over the course of approximately 1 year. This research includes a brief daily diary (~1 minute daily) in addition to up to 7 in-person meetings: 1 medical screening meeting (~3 hrs total); 2 pre-performance meetings (~1 hr each); 2 performance sessions (~4 hrs each); and 2 follow-up meetings (~1 hr each).

If you are a non-smoker, we expect that you will be in this research study for a total of up to around 13-25 hours over the course of about 1-2 months. This research includes a brief daily diary (~1 minute daily) in addition to up to 5 meetings: 1 medical screening meeting (~3 hrs total); 2 pre-performance meetings (~1 hr each); and 2 performance sessions (~4 hrs each).

What will I be doing in the study?

In addition to the activities listed above:

• smokers will be required to quit smoking 15 hours prior to each performance session

• all participants will take naltrexone or placebo during each performance session

• smokers will complete 4 smoking cessation counseling sessions

• non-smokers will complete 2 behavior change counseling session

Will I be compensated?

Compensation will be shared with participants if deemed

eligible to participate.

What should I do if I'm interested?

Please complete the online screen by visiting the following link

For questions or concerns, please email bml-tc@d.umn.edu.